About Enhancer
| Enhancer ID: | E_03568 |
| Species: | Homo sapiens |
| Position : | chr3:172549013-172551013   |
| Year: | 2023 |
| Title: | An enhancer variant associated with breast cancer susceptibility in Black women regulates TNFSF10 expression and antitumor immunity in triple-negative breast cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | triple-negative breast carcinoma |
| PMID: | 35930348 |
| MONDO: | MONDO:0005494 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | HCC1806 |
| CVCL ID: | CVCL_1258 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer variant functional assay; TF binding assay; genome editing assay |
| High Throughput Method: | GWAS; eQTL analysis; ENCODE epigenomic data analysis |
| Low Throughput Method: | CRISPR-Cas9 HDR editing; EMSA; supershift assay; RT-qPCR; Western blot; apoptosis assay |
About Target Gene
| Target gene : | TNFSF10 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer