About Enhancer
| Enhancer ID: | E_03570 |
| Species: | Homo sapiens |
| Position : | chr2:177480000-177490000   |
| Year: | 2022 |
| Title: | Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioma |
| PMID: | 35390275 |
| MONDO: | MONDO:0021042 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | normal human cortical astrocytes |
| Cell Type: | astrocyte |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Enhancer activity assay; eRNA assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | RNA-seq; Hi-C; 4C-seq; ChIP-seq |
| Low Throughput Method: | LINC01116 knockdown; enhancer activation; ChIP-qPCR; RT-qPCR; glioma-cell viability and astrocyte-transformation assays |
About Target Gene
| Target gene : | MIR10B |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer