About Enhancer
| Enhancer ID: | E_03577 |
| Species: | Homo sapiens |
| Position : | chr8:130180065-130180972   |
| Year: | 2018 |
| Title: | Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 30107177 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | NUP214-ABL1/TLX1-positive T-ALL cells |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | TLX1 downregulation; STAT5 pathway inhibition; MYC perturbation; BET inhibition; gene-expression assay; cell-death assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | TLX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
67 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02010 | chr8:130179643-130181490 | blood / hematopoietic system | T cell | T-cell acute lymphoblastic leukemia |
| E_00455 | chr8:130180012-130180748 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01422 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01423 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01424 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01425 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01426 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01427 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01428 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01429 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01435 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01436 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01437 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01438 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01980 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01981 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01982 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01983 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01988 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01989 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01990 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01991 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01992 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01993 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01994 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01995 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01996 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01997 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01998 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01999 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02000 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_02001 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02002 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02003 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02007 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02008 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03525 | chr8:130180065-130180972 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03541 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03542 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03545 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03546 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03547 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03548 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03549 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04520 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04526 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04527 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04528 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04529 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01368 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01369 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01414 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01415 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01416 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01417 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01418 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01419 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01420 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01421 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_03543 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03544 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03551 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03552 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03553 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03554 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04512 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04513 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer