About Enhancer
| Enhancer ID: | E_03586 |
| Species: | Mus musculus |
| Position : | chr10:118255061-118255451   |
| Year: | 2014 |
| Title: | Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24415943 |
| Cell Source: | primary mouse CD4-positive T cells |
| Cell Type: | T helper 1 cell |
| Cell Ontology ID: | CL:0000545 |
| Experiment Type: | Endogenous enhancer deletion assay; Epigenetic mechanism assay; TF binding assay |
| High Throughput Method: | DNase-seq/open-chromatin profiling; ChIP-chip |
| Low Throughput Method: | Conditional CNS-22 deletion; cytokine/TCR stimulation; histone H3/H4 acetylation ChIP; RNA polymerase II ChIP; RT-qPCR |
About Target Gene
| Target gene : | Ifng |
About TF
| TF name : | Tbx21 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx21 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Tbx21 | Glucocorticoid receptor regulatory network | pid | 85 |
| Tbx21 | IL12-mediated signaling events | pid | 62 |
| Tbx21 | IL12 signaling mediated by STAT4 | pid | 33 |
| Tbx21 | IL27-mediated signaling events | pid | 26 |
| Tbx21 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer