About Enhancer
| Enhancer ID: | E_03594 |
| Species: | Mus musculus |
| Position : | chr9:60714330-60714960   |
| Year: | 2017 |
| Title: | Myeloid Zinc Finger 1 and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 in Cancer Cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | osteosarcoma |
| PMID: | 28905448 |
| MONDO: | MONDO:0009807 |
| Tissue: | bone tissue |
| Tissue Ontology ID: | UBERON:0002481 |
| Cell Source: | mOS-482 |
| Cell Type: | murine osteosarcoma cell |
| Experiment Type: | Enhancer activity assay; TF binding assay |
| Low Throughput Method: | Scanning mutagenesis; luciferase reporter assay; EMSA/supershift assay; transcription-factor depletion; RT-qPCR; Western blot |
About Target Gene
| Target gene : | Yap1 |
About TF
| TF name : | Gabpa |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gabpa | PDGF signaling pathway | panther | 113 |
| Gabpa | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Gabpa | Hs_Energy_Metabolism_WP1541_91584 | wikipathways | 13 |
| Gabpa | Hs_Mitochondrial_Gene_Expression_WP391_71373 | wikipathways | 11 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03597 | chr9:60714330-60714960 | bone tissue | murine osteosarcoma cell | osteosarcoma |
Expression of Target Genes for the Enhancer