About Enhancer
| Enhancer ID: | E_03599 |
| Species: | Mus musculus |
| Position : | chr15:52153900-52154520   |
| Year: | 2011 |
| Title: | The pancreatic islet ζ±-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20942803 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | #NAME? |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer activity assay; cell-type specificity assay; direct TF binding |
| Low Throughput Method: | VISTA conservation; luciferase reporter; orientation testing; EMSA; PDX1 ChIP; PDX1-site mutagenesis |
About Target Gene
| Target gene : | Slc30a8 |
About TF
| TF name : | Pdx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pdx1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Pdx1 | Regulation of gene expression in beta cells | reactome | 17 |
| Pdx1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| Pdx1 | Type II diabetes mellitus | kegg | 44 |
| Pdx1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer