About Enhancer
| Enhancer ID: | E_03600 |
| Species: | Mus musculus |
| Position : | chr15:52315878-52316077   |
| Year: | 2011 |
| Title: | The pancreatic islet ζ±-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20942803 |
| Tissue: | islet of Langerhans |
| Tissue Ontology ID: | UBERON:0000006 |
| Cell Source: | Beta-TC-3 |
| CVCL ID: | CVCL_0172 |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer-core dissection; TF-site mutagenesis; reporter assay |
| High Throughput Method: | Comparative sequence conservation analysis |
| Low Throughput Method: | Dual-luciferase reporter assay; orientation test; Pdx1-site mutagenesis; EMSA |
About Target Gene
| Target gene : | Slc30a8 |
About TF
| TF name : | Pdx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pdx1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Pdx1 | Regulation of gene expression in beta cells | reactome | 17 |
| Pdx1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| Pdx1 | Type II diabetes mellitus | kegg | 44 |
| Pdx1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03596 | chr15:52315678-52316298 | islet of Langerhans | pancreatic beta cell | NA |
| E_03601 | chr15:52315678-52316298 | pancreas | pancreatic beta cell | NA |
| E_03605 | chr15:52315678-52316298 | pancreas | pancreatic beta cell | NA |
| E_04922 | chr15:52315678-52316298 | islet of Langerhans | pancreatic beta cell | NA |
| E_04926 | chr15:52315678-52316298 | NA | NA | Type 2 Diabetes Mellitus |
| E_03590 | chr15:52316013-52316633 | islet of Langerhans | pancreatic beta cell | NA |
| E_03610 | chr15:52316013-52316633 | islet of Langerhans | pancreatic alpha cell | NA |
Expression of Target Genes for the Enhancer