About Enhancer
| Enhancer ID: | E_03612 |
| Species: | Homo sapiens |
| Position : | chr5:133050976-133051978   |
| Year: | 2026 |
| Title: | Redistribution of super-enhancers promotes malignancy in human hepatocellular carcinoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 40617410 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HCCLM3 |
| CVCL ID: | CVCL_6832 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Super-enhancer activity assay; Functional perturbation assay; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 deletion of SE-signal regulatory region; H3K27ac ChIP-qPCR; BRD4 ChIP-qPCR; RT-qPCR; Western blot; JQ1 treatment; colony formation assay; migration assay; xenograft assay; HSPA4 rescue assay; CRISPR-Cas9 endogenous deletion/editing; ChIP; Xenograft/xenotransplant |
About Target Gene
| Target gene : | HSPA4 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer