About Enhancer
| Enhancer ID: | E_03614 |
| Species: | Homo sapiens |
| Position : | chr2:239200000-239250000   |
| Year: | 2025 |
| Title: | HDAC4 super-enhancer drives CEBPB-mediated TWIST2 transcription to promote chemoresistance in LUAD. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 40222483 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | H4-II-E-C3 |
| CVCL ID: | CVCL_0285 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR knockout; Luciferase reporter assay; ChIP-RT-qPCR; RT-RT-qPCR; Western blot |
About Target Gene
| Target gene : | TWIST2 |
About TF
| TF name : | CEBPB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPB | C-MYB transcription factor network | pid | 87 |
| CEBPB | EGFR1 | netpath | 475 |
| CEBPB | FOXA1 transcription factor network | pid | 45 |
| CEBPB | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPB | IFN-gamma pathway | pid | 43 |
| CEBPB | IL3-mediated signaling events | pid | 27 |
| CEBPB | IL4-mediated signaling events | pid | 66 |
| CEBPB | IL4 | netpath | 75 |
| CEBPB | IL6-mediated signaling events | pid | 48 |
| CEBPB | IL6 | netpath | 85 |
| CEBPB | RANKL | netpath | 84 |
| CEBPB | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| CEBPB | Regulation of retinoblastoma protein | pid | 67 |
| CEBPB | Senescence-Associated Secretory Phenotype (SASP) | reactome | 108 |
| CEBPB | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| CEBPB | TCR | netpath | 261 |
| CEBPB | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPB | Validated nuclear estrogen receptor alpha network | pid | 65 |
| CEBPB | Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 | wikipathways | 62 |
| CEBPB | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| CEBPB | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
| CEBPB | Hs_Lung_fibrosis_WP3624_91475 | wikipathways | 23 |
| CEBPB | Hs_IL17_signaling_pathway_WP2112_89838 | wikipathways | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer