About Enhancer
| Enhancer ID: | E_03616 |
| Species: | Homo sapiens |
| Position : | chr7:54960823-54970827   |
| Year: | 2024 |
| Title: | A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS-RAF1-MEK1/2-ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | nasopharyngeal carcinoma |
| PMID: | 38943090 |
| MONDO: | MONDO:0015459 |
| Tissue: | nasopharynx |
| Tissue Ontology ID: | UBERON:0001728 |
| Cell Source: | S18 |
| CVCL ID: | CVCL_B0U9 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq; RNA-seq; ChIP-seq |
| Low Throughput Method: | CRISPR Knockout, qRT-PCR, Western blot; ChIP; In vivo phenotyping |
About Target Gene
| Target gene : | EGFR |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer