About Enhancer
| Enhancer ID: | E_03618 |
| Species: | Homo sapiens |
| Position : | chr19:13110271-13175850   |
| Year: | 2022 |
| Title: | Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 35842703 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | NB4 |
| CVCL ID: | CVCL_0005 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Super enhancer activity assay, Functional perturbation assay; TF binding assay; Chromatin-state profiling |
| High Throughput Method: | ChIP-seq, RNA-seq; RNA-seq; ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, RT-RT-qPCR; ChIP; RT-qPCR; Western blot; Flow cytometry; shRNA knockdown |
About Target Gene
| Target gene : | LYL1 |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer