About Enhancer
| Enhancer ID: | E_03627 |
| Species: | Homo sapiens |
| Position : | chr11:5241525-5251525   |
| Year: | 2016 |
| Title: | Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27863249 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary erythroblasts |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | ChIP-seq, ATAC-seq, Hi-C; Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, RT-qPCR |
About Target Gene
| Target gene : | HBB |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_03342 | chr11:5246600-5247600 | kidney | embryonic kidney cell | NA |
| E_05110 | chr11:5248027-5248047 | blood / hematopoietic system | NA | NA |
| E_05111 | chr11:5248027-5248047 | blood / hematopoietic system | NA | NA |
| E_05351 | chr11:5248824-5249485 | NA | NA | NA |
| E_05352 | chr11:5248824-5249485 | NA | NA | NA |
| E_05106 | chr11:5250264-5250295 | blood / hematopoietic system | NA | NA |
| E_05107 | chr11:5250264-5250295 | blood / hematopoietic system | NA | NA |
| E_05108 | chr11:5250535-5250560 | blood / hematopoietic system | NA | NA |
| E_05109 | chr11:5250535-5250560 | blood / hematopoietic system | NA | NA |
| E_05114 | chr11:5250704-5250719 | blood / hematopoietic system | NA | NA |
| E_05115 | chr11:5250704-5250719 | blood / hematopoietic system | NA | NA |
| E_05112 | chr11:5250751-5250777 | blood / hematopoietic system | NA | NA |
| E_05113 | chr11:5250751-5250777 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer