About Enhancer
| Enhancer ID: | E_03640 |
| Species: | Homo sapiens |
| Position : | chr21:43772291-43774291   |
| Year: | 2014 |
| Title: | Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Mixed-Lineage Leukemia 1 |
| PMID: | 24288367 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | KMT2A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KMT2A | PKMTs methylate histone lysines | reactome | 64 |
| KMT2A | Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04616 | chr21:43770915-43772915 | breast | malignant cell | breast cancer |
| E_04633 | chr21:43770915-43772915 | breast | NA | NA |
| E_04634 | chr21:43770915-43772915 | breast | NA | NA |
| E_03643 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03644 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03645 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03641 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03642 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
Expression of Target Genes for the Enhancer