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Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03646
Species: Mus musculus
Position : chr8:123455000-123472000
Year: 2020
Title: Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  32694829
Tissue: kidney
Tissue Ontology ID: UBERON:0002113
Cell Source: Pkd1-heterozygous renal tubular epithelial cells
Cell Type: kidney tubular epithelial cell
Experiment Type: Enhancer activity assay; Functional perturbation assay
High Throughput Method: ChIP-seq; RNA-seq; ATAC-seq
Low Throughput Method: ChIP-qPCR; RT-qPCR; Western blot
About Target Gene
Target gene : Ampd3
About TF
TF name : Cdk7
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Cdk7 AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 173
Cdk7 AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) inoh 173
Cdk7 AndrogenReceptor netpath 167
Cdk7 BCR netpath 161
Cdk7 Cyclin A/B1 associated events during G2/M transition reactome 22
Cdk7 Cyclin A:Cdk2-associated events at S phase entry reactome 15
Cdk7 Cyclin D associated events in G1 reactome 38
Cdk7 Cyclin E associated events during G1/S transition reactome 14
Cdk7 Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) inoh 236
Cdk7 Dual incision in TC-NER reactome 63
Cdk7 Formation of HIV-1 elongation complex containing HIV-1 Tat reactome 42
Cdk7 Formation of HIV elongation complex in the absence of HIV Tat reactome 44
Cdk7 Formation of Incision Complex in GG-NER reactome 43
Cdk7 Formation of RNA Pol II elongation complex reactome 44
Cdk7 Formation of TC-NER Pre-Incision Complex reactome 53
Cdk7 Formation of the Early Elongation Complex reactome 33
Cdk7 Formation of the HIV-1 Early Elongation Complex reactome 33
Cdk7 Gap-filling DNA repair synthesis and ligation in TC-NER reactome 62
Cdk7 HIV Transcription Initiation reactome 44
Cdk7 mRNA Capping reactome 29
Cdk7 NoRC negatively regulates rRNA expression reactome 104
Cdk7 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
Cdk7 Retinoic acid receptors-mediated signaling pid 30
Cdk7 RNA Pol II CTD phosphorylation and interaction with CE reactome 27
Cdk7 RNA Polymerase I Chain Elongation reactome 88
Cdk7 RNA Polymerase I Promoter Escape reactome 30
Cdk7 RNA Polymerase I Transcription Initiation reactome 47
Cdk7 RNA Polymerase I Transcription Termination reactome 31
Cdk7 RNA Polymerase II HIV Promoter Escape reactome 44
Cdk7 RNA Polymerase II Pre-transcription Events reactome 64
Cdk7 RNA Polymerase II Promoter Escape reactome 44
Cdk7 RNA polymerase II transcribes snRNA genes reactome 70
Cdk7 RNA Polymerase II Transcription Elongation reactome 42
Cdk7 RNA Polymerase II Transcription Initiation And Promoter Clearance reactome 44
Cdk7 RNA Polymerase II Transcription Initiation reactome 44
Cdk7 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening reactome 44
Cdk7 Tat-mediated elongation of the HIV-1 transcript reactome 40
Cdk7 TP53 Regulates Transcription of DNA Repair Genes reactome 61
Cdk7 Transcription-Coupled Nucleotide Excision Repair (TC-NER) reactome 44
Cdk7 Transcription of the HIV genome reactome 44
Cdk7 VEGF signaling pathway ( VEGF signaling pathway ) inoh 183
Cdk7 Cell cycle kegg 124
Cdk7 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
Cdk7 Hs_Nucleotide_Metabolism_WP404_68960 wikipathways 16
Cdk7 Hs_Steroid_Biosynthesis_WP496_69016 wikipathways 8
Enhancer Associated Network
Overlapping Enhancers (mm10) 1 found
Enhancer ID Position Tissue Cell Disease
E_03623 chr8:123455000-123472000 kidney kidney epithelial cell polycystic kidney disease
Expression of Target Genes for the Enhancer