About Enhancer
| Enhancer ID: | E_03647 |
| Species: | Homo sapiens |
| Position : | chr17:62028371-62028917   |
| Year: | 2011 |
| Title: | Enhancer-blocking activity is associated with hypersensitive site V sequences in the human growth hormone locus control region. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21711161 |
| Tissue: | pituitary gland |
| Tissue Ontology ID: | UBERON:0000007 |
| Cell Source: | HEK293 |
| CVCL ID: | CVCL_0045 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer-blocking assay; TF association assay; functional perturbation assay; In vivo functional validation |
| Low Throughput Method: | Enhancer-blocking reporter assay; ChIP; YY1 RNA interference; DNA methylation analysis; In vivo phenotyping |
About Target Gene
| Target gene : | GH1 |
About TF
| TF name : | YY1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
Expression of Target Genes for the Enhancer