About Enhancer
| Enhancer ID: | E_03653 |
| Species: | Homo sapiens |
| Position : | chr2:221040922-221069549   |
| Year: | 2016 |
| Title: | Active medulloblastoma enhancers reveal subgroup-specific cellular origins. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Medulloblastoma |
| PMID: | 26814967 |
| MONDO: | MONDO:0007959 |
| Cell Source: | Medulloblastoma Cell Lines |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; RNA-seq; 4C-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | HLX |
About TF
| TF name : | SOX2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| SOX2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| SOX2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| SOX2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| SOX2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| SOX2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| SOX2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SOX2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer