About Enhancer
| Enhancer ID: | E_03671 |
| Species: | Mus musculus |
| Position : | chr14:67743318-67743610   |
| Year: | 2012 |
| Title: | Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22877652 |
| Cell Source: | GT1-7 |
| CVCL ID: | CVCL_0281 |
| Cell Type: | GnRH neuron |
| Cell Ontology ID: | CL:0011111 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional cis-element perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; reporter truncation analysis; site-directed mutagenesis; ChIP-qPCR; EMSA; AR overexpression; AR DNA-binding-domain mutant analysis; R1881 treatment |
About Target Gene
| Target gene : | Gnrh1 |
About TF
| TF name : | Ar |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ar | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| Ar | Alpha6Beta4Integrin | netpath | 74 |
| Ar | AndrogenReceptor | netpath | 167 |
| Ar | Coregulation of Androgen receptor activity | pid | 61 |
| Ar | FOXA1 transcription factor network | pid | 45 |
| Ar | IL6 | netpath | 85 |
| Ar | Nongenotropic Androgen signaling | pid | 31 |
| Ar | Notch-mediated HES/HEY network | pid | 48 |
| Ar | Nuclear Receptor transcription pathway | reactome | 51 |
| Ar | Regulation of Androgen receptor activity | pid | 54 |
| Ar | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Ar | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Ar | TGF_beta_Receptor | netpath | 220 |
| Ar | Oocyte meiosis | kegg | 110 |
| Ar | Pathways in cancer | kegg | 321 |
| Ar | Prostate cancer | kegg | 85 |
| Ar | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| Ar | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| Ar | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| Ar | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| Ar | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05205 | chr14:67741735-67744661 | gonad | NA | NA |
Expression of Target Genes for the Enhancer