About Enhancer
| Enhancer ID: | E_03677 |
| Species: | Homo sapiens |
| Position : | chr17:62028378-62028924   |
| Year: | 2011 |
| Title: | Enhancer-blocking activity is associated with hypersensitive site V sequences in the human growth hormone locus control region. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21711161 |
| Cell Source: | HEK-293 |
| CVCL ID: | CVCL_0045 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | GH1 |
About TF
| TF name : | YY1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03633 | chr17:62028371-62028917 | pituitary gland | epithelial cell | NA |
| E_03647 | chr17:62028371-62028917 | pituitary gland | epithelial cell | NA |
| E_03673 | chr17:62028378-62028924 | NA | malignant cell | NA |
| E_03674 | chr17:62028378-62028924 | NA | malignant cell | NA |
| E_03676 | chr17:62028378-62028924 | NA | NA | NA |
Expression of Target Genes for the Enhancer