About Enhancer
| Enhancer ID: | E_03678 |
| Species: | Homo sapiens |
| Position : | chr7:5509938-5510616   |
| Year: | 2019 |
| Title: | CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 31300060 |
| MONDO: | MONDO:0018177 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U373MG/T98G-derived GSC model |
| Cell Type: | glioma stem-like cell |
| Experiment Type: | CEBPD binds PDGFA promoter (~-538 to +70); this paper does not establish the supplied chr7 interval as an enhancer |
| High Throughput Method: | microarray |
| Low Throughput Method: | PDGFA promoter luciferase assay; CEBPD ChIP; RT-qPCR; Western blot; stemness assays; Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | PDGFA |
About TF
| TF name : | CEBPD |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPD | C-MYB transcription factor network | pid | 87 |
| CEBPD | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPD | IL6-mediated signaling events | pid | 48 |
| CEBPD | Regulation of retinoblastoma protein | pid | 67 |
| CEBPD | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPD | Validated targets of C-MYC transcriptional repression | pid | 63 |
| CEBPD | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03626 | chr7:5509938-5510616 | brain | glioma stem cell | glioblastoma |
Expression of Target Genes for the Enhancer