About Enhancer
| Enhancer ID: | E_03680 |
| Species: | Homo sapiens |
| Position : | chr8:128740000-128750000   |
| Year: | 2024 |
| Title: | RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | myeloid malignancy |
| PMID: | 38513139 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, GRID-seq, RNA-seq |
| Low Throughput Method: | CUT&RUN-RT-qPCR, shRNA Knockdown, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | FOXK2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer