About Enhancer
| Enhancer ID: | E_03682 |
| Species: | Homo sapiens |
| Position : | chr6:138226720-138233280   |
| Year: | 2018 |
| Title: | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Autoimmune Diseases |
| PMID: | 29440643 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | B Cell,Monocytes |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; Hi-C |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | TNFAIP3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03443 | chr6:138229810-138230149 | bone marrow | malignant cell | systemic lupus erythematosus |
| E_03450 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03451 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03452 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03453 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03526 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03527 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03528 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03529 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03534 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03535 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03536 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03537 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
Expression of Target Genes for the Enhancer