About Enhancer
| Enhancer ID: | E_03683 |
| Species: | Homo sapiens |
| Position : | chr8:38291071-38304326   |
| Year: | 2018 |
| Title: | Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 30033119 |
| Cell Source: | Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Endogenous enhancer perturbation |
| High Throughput Method: | STARR-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | FGFR1 |
About TF
| TF name : | POU5F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| POU5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| POU5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| POU5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer