About Enhancer
| Enhancer ID: | E_03686 |
| Species: | Mus musculus |
| Position : | chr10:12845744-12845755   |
| Year: | 2011 |
| Title: | Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21887706 |
| Tissue: | cartilage tissue |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | Hypertrophic MCT chondrocytes |
| Cell Type: | hypertrophic chondrocyte |
| Cell Ontology ID: | CL:0000743 |
| Experiment Type: | TF binding assay; Enhancer activity assay; Endogenous enhancer perturbation; In vivo functional validation |
| Low Throughput Method: | EMSA; Transgenic enhancer reporter assay; ChIP; Site-directed/motif mutagenesis; In vivo phenotyping; Reporter assay |
About Target Gene
| Target gene : | Col10a1 |
About TF
| TF name : | Runx2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx2 | AndrogenReceptor | netpath | 167 |
| Runx2 | FGF signaling pathway | pid | 55 |
| Runx2 | Leptin | netpath | 98 |
| Runx2 | Notch-mediated HES/HEY network | pid | 48 |
| Runx2 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx2 | Regulation of retinoblastoma protein | pid | 67 |
| Runx2 | TGF_beta_Receptor | netpath | 220 |
| Runx2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Runx2 | Hs_MAPK_Signaling_Pathway_WP382_79951 | wikipathways | 58 |
| Runx2 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Runx2 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Runx2 | Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 | wikipathways | 6 |
| Runx2 | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer