About Enhancer
| Enhancer ID: | E_03689 |
| Species: | Homo sapiens |
| Position : | chr8:127329840-127331840   |
| Year: | 2023 |
| Title: | Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | group 3 medulloblastoma |
| PMID: | 37945900 |
| MONDO: | MONDO:0007959 |
| Tissue: | cerebrospinal fluid |
| Tissue Ontology ID: | UBERON:0001359 |
| Cell Source: | D458 Med |
| CVCL ID: | CVCL_1161 |
| Cell Type: | medulloblastoma cell |
| Experiment Type: | ecDNA MYC super-enhancer CRISPRi target site; Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | whole-genome sequencing; optical genome mapping; ATAC-seq; Hi-C; pooled CRISPRi screen; RNA-seq |
| Low Throughput Method: | individual CRISPRi validation; RT-qPCR; DNA-FISH; RNA-FISH |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
Expression of Target Genes for the Enhancer