Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03691
Species: Homo sapiens
Position : chr8:127330655-127330840
Year: 2023
Title: Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.
Genome Build: hg38
Enhancer Type: Super-enhancer
Condition: Disease
Disease Name: Medulloblastoma
PMID:  37945900
MONDO: MONDO:0007959
Tissue: brain
Tissue Ontology ID: UBERON:0000955
Cell Source: D-423MG
CVCL ID: CVCL_1160
Cell Type: medulloblastoma cell
Experiment Type: Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay
High Throughput Method: Hi-C; ATAC-seq; RNA-seq
Low Throughput Method: CRISPRi, qRT-PCR; FISH
About Target Gene
Target gene : MYC
About TF
TF name : NA
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (hg38) 3 found
Enhancer ID Position Tissue Cell Disease
E_03876 chr8:126650000-129950000 colon malignant cell NA
E_03689 chr8:127329840-127331840 cerebrospinal fluid medulloblastoma cell group 3 medulloblastoma
E_03690 chr8:127329927-127331927 cerebrospinal fluid medulloblastoma cell group 3 medulloblastoma
Expression of Target Genes for the Enhancer