About Enhancer
| Enhancer ID: | E_03698 |
| Species: | Homo sapiens |
| Position : | chr6:132265000-132266500   |
| Year: | 2019 |
| Title: | Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 30649550 |
| MONDO: | MONDO:0004989 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay, TF binding assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR knockout; ChIP-RT-qPCR; RT-RT-qPCR; Western blot; Co-IP |
About Target Gene
| Target gene : | CCN2 |
About TF
| TF name : | TEAD1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TEAD1 | PPARA activates gene expression | reactome | 113 |
| TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| TEAD1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer