About Enhancer
| Enhancer ID: | E_03715 |
| Species: | Homo sapiens |
| Position : | chr8:127047315-127049315   |
| Year: | 2013 |
| Title: | Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Acute Leukemia |
| PMID: | 24285714 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Acute Myeloid Leukemia Cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C; 4C; RT-qPCR/qPCR; RNAi/siRNA/shRNA |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | ERG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ERG | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ERG | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ERG | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ERG | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ERG | PDGF signaling pathway | panther | 113 |
| ERG | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03713 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03714 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03716 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03717 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
Expression of Target Genes for the Enhancer