About Enhancer
| Enhancer ID: | E_03717 |
| Species: | Homo sapiens |
| Position : | chr8:127047315-127049315   |
| Year: | 2013 |
| Title: | Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Acute Leukemia |
| PMID: | 24285714 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Acute Myeloid Leukemia Cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C; 4C; RT-qPCR/qPCR; RNAi/siRNA/shRNA |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | SMARCA4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SMARCA4 | BMP signaling in Drosophila ( BMP signaling in Drosophila ) | inoh | 7 |
| SMARCA4 | BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) | inoh | 7 |
| SMARCA4 | BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) | inoh | 7 |
| SMARCA4 | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 |
| SMARCA4 | Direct p53 effectors | pid | 141 |
| SMARCA4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| SMARCA4 | Glucocorticoid receptor regulatory network | pid | 85 |
| SMARCA4 | RANKL | netpath | 84 |
| SMARCA4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| SMARCA4 | Regulation of retinoblastoma protein | pid | 67 |
| SMARCA4 | RMTs methylate histone arginines | reactome | 75 |
| SMARCA4 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| SMARCA4 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| SMARCA4 | TNFalpha | netpath | 274 |
| SMARCA4 | Validated nuclear estrogen receptor beta network | pid | 15 |
| SMARCA4 | Wnt signaling pathway | panther | 250 |
| SMARCA4 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03713 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03714 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03715 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
| E_03716 | chr8:127047315-127049315 | blood / hematopoietic system | malignant cell | Acute Leukemia |
Expression of Target Genes for the Enhancer