About Enhancer
| Enhancer ID: | E_03745 |
| Species: | Homo sapiens |
| Position : | chr11:8255155-8255707   |
| Year: | 2015 |
| Title: | Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | neuroblastoma |
| PMID: | 26560027 |
| MONDO: | MONDO:0005072 |
| Cell Source: | SK-N-SH |
| CVCL ID: | CVCL_0531 |
| Cell Type: | neuroblastoma cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional variant assay; Genetic association analysis |
| High Throughput Method: | GWAS/imputation; GATA3 ChIP-seq; H3K27ac ChIP-seq; RNA-seq; DNase-seq |
| Low Throughput Method: | Luciferase Reporter Assay; Allele-specific reporter assay; Genotyping; Allele-specific expression analysis; ChIP-qPCR; Sanger sequencing; Reporter assay |
About Target Gene
| Target gene : | LMO1 |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer