About Enhancer
| Enhancer ID: | E_03746 |
| Species: | Homo sapiens |
| Position : | chr2:73956813-73957241   |
| Year: | 2022 |
| Title: | Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p13.1. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 35741778 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | LCL |
| Cell Type: | lymphoblastoid cell line |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | Hi-C; Capture Hi-C; eQTL analysis |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; ChIP-qPCR; qPCR; Western blot |
About Target Gene
| Target gene : | DGUOK-AS1 |
About TF
| TF name : | ARID3A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ARID3A | Direct p53 effectors | pid | 141 |
| ARID3A | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | reactome | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03692 | chr2:73956813-73957241 | blood | B cell | systemic lupus erythematosus |
Expression of Target Genes for the Enhancer