About Enhancer
| Enhancer ID: | E_03747 |
| Species: | Homo sapiens |
| Position : | chr8:128482317-128483854   |
| Year: | 2009 |
| Title: | The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. |
| Genome Build: | hg18 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 19561607 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | LS174T |
| CVCL ID: | CVCL_1384 |
| Cell Type: | epithelial cell of colon |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Allele-specific regulatory assay |
| High Throughput Method: | TCF7L2 ChIP-chip; Affymetrix Human Tiling 2.0R array |
| Low Throughput Method: | Luciferase reporter assay; allele-specific reporter assay; TCF7L2 allele-specific ChIP; Sequenom MALDI-TOF allele quantification; 3C; competitive PCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | TCF7L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF7L2 | Alzheimer disease-presenilin pathway | panther | 98 |
| TCF7L2 | Angiogenesis | panther | 141 |
| TCF7L2 | AP-1 transcription factor network | pid | 71 |
| TCF7L2 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| TCF7L2 | Ca2+ pathway | reactome | 62 |
| TCF7L2 | Cadherin signaling pathway | panther | 147 |
| TCF7L2 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| TCF7L2 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF7L2 | ID | netpath | 38 |
| TCF7L2 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| TCF7L2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF7L2 | Repression of WNT target genes | reactome | 14 |
| TCF7L2 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| TCF7L2 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| TCF7L2 | Wnt | netpath | 118 |
| TCF7L2 | Wnt signaling pathway | panther | 250 |
| TCF7L2 | Wnt signaling pathway | kegg | 135 |
| TCF7L2 | Adherens junction | kegg | 70 |
| TCF7L2 | Melanogenesis | kegg | 100 |
| TCF7L2 | Pathways in cancer | kegg | 321 |
| TCF7L2 | Colorectal cancer | kegg | 63 |
| TCF7L2 | Endometrial cancer | kegg | 52 |
| TCF7L2 | Prostate cancer | kegg | 85 |
| TCF7L2 | Acute myeloid leukemia | kegg | 53 |
| TCF7L2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg18)
3 found
Expression of Target Genes for the Enhancer