About Enhancer
| Enhancer ID: | E_03819 |
| Species: | Mus musculus |
| Position : | chr17:26531508-26539010   |
| Year: | 2024 |
| Title: | Engrailed-1 Promotes Pancreatic Cancer Metastasis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 38110836 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | KPC-derived mT3-2D cells |
| Cell Type: | pancreatic ductal cell |
| Cell Ontology ID: | CL:0002079 |
| Experiment Type: | TF binding assay; Enhancer chromatin-state assay; Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | FLAG-En1 CUT&RUN-seq; H3K27ac CUT&RUN-seq; H3K4me3 CUT&RUN-seq |
| Low Throughput Method: | In vivo phenotyping |
About Target Gene
| Target gene : | Dusp1 |
About TF
| TF name : | En1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| En1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer