About Enhancer
| Enhancer ID: | E_03827 |
| Species: | Mus musculus |
| Position : | chr12:113232344-113232426   |
| Year: | 2024 |
| Title: | Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 39413158 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary splenic B cells (mature resting and LPS-stimulated) |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Functional genetic perturbation assay; Chromatin accessibility assay; Chromatin topology assay; Nuclear positioning assay; Class switch recombination assay |
| High Throughput Method: | ATAC-seq; 3C-HTGTS; LAM-HTGTS |
| Low Throughput Method: | Genetic deletion mouse models (Delta3'RR and c3'RR); DNA 3D-FISH; 3C-qPCR; ATAC-qPCR; Flow cytometry |
About Target Gene
| Target gene : | Igh |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04615 | chr12:113220000-113233375 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04628 | chr12:113220000-113233375 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04629 | chr12:113220000-113233375 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04631 | chr12:113220000-113255414 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04632 | chr12:113220000-113255414 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
Expression of Target Genes for the Enhancer