About Enhancer
| Enhancer ID: | E_03846 |
| Species: | Homo sapiens |
| Position : | chr1:23881330-23881475   |
| Year: | 2015 |
| Title: | TGF-ζ±1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25505291 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary human monocyte-derived macrophages |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer activity assay; Signaling perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; ECR deletion analysis; TGF-beta1 stimulation; BMP stimulation; SMAD overexpression; SMAD knockdown; ALK inhibition; RT-qPCR; Western blot; Reporter assay |
About Target Gene
| Target gene : | ID3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03888 | chr1:23881244-23881761 | NA | macrophage | Cardiometabolic Disorders |
Expression of Target Genes for the Enhancer