About Enhancer
| Enhancer ID: | E_03868 |
| Species: | Homo sapiens |
| Position : | chr13:28843000-28843500   |
| Year: | 2023 |
| Title: | MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
| PMID: | 37626123 |
| MONDO: | MONDO:0004967 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | SEM |
| CVCL ID: | CVCL_0095 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Fusion-protein occupancy assay; Chromatin interaction assay; Enhancer chromatin-state assay; Functional protein-degradation perturbation |
| High Throughput Method: | MLL/AF4/H3K27ac ChIP-seq or TOPmentation; ATAC-seq; Micro-Capture-C; Capture-C; Micro-C |
| Low Throughput Method: | MLL-AF4 knockdown; PAF1/FACT degron perturbation; targeted Capture-C/MCC validation; RT-qPCR |
About Target Gene
| Target gene : | FLT3 |
About TF
| TF name : | KMT2A::AFF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02624 | chr13:28840000-28850000 | blood | precursor B cell | KMT2A-rearranged acute lymphoblastic leukemia |
| E_02625 | chr13:28840000-28850000 | blood | precursor B cell | KMT2A-rearranged acute lymphoblastic leukemia |
| E_03831 | chr13:28843000-28843500 | blood | B cell | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
| E_03832 | chr13:28843000-28843500 | bone marrow | B-lymphoblast | B-cell acute lymphoblastic leukemia |
| E_03867 | chr13:28843000-28843500 | blood | B cell | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
| E_03869 | chr13:28843000-28843500 | bone marrow | B-lymphoblast | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer