About Enhancer
| Enhancer ID: | E_03869 |
| Species: | Homo sapiens |
| Position : | chr13:28843000-28843500   |
| Year: | 2020 |
| Title: | 13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 32384149 |
| MONDO: | MONDO:0004947 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | NALM-6 |
| CVCL ID: | CVCL_0092 |
| Cell Type: | B-lymphoblast |
| Cell Ontology ID: | CL:0017006 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C, PLAC-seq, ATAC-seq, DNase-seq |
| Low Throughput Method: | RT-RT-qPCR, FISH |
About Target Gene
| Target gene : | FLT3 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02624 | chr13:28840000-28850000 | blood | precursor B cell | KMT2A-rearranged acute lymphoblastic leukemia |
| E_02625 | chr13:28840000-28850000 | blood | precursor B cell | KMT2A-rearranged acute lymphoblastic leukemia |
| E_03831 | chr13:28843000-28843500 | blood | B cell | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
| E_03832 | chr13:28843000-28843500 | bone marrow | B-lymphoblast | B-cell acute lymphoblastic leukemia |
| E_03867 | chr13:28843000-28843500 | blood | B cell | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
| E_03868 | chr13:28843000-28843500 | blood | B cell | KMT2A::AFF1-rearranged B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer