About Enhancer
| Enhancer ID: | E_03887 |
| Species: | Mus musculus |
| Position : | chr4:136140654-136141162   |
| Year: | 2015 |
| Title: | TGF-ζ±1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25505291 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep G2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; Western blot; RNAi/siRNA/shRNA |
About Target Gene
| Target gene : | Id3 |
About TF
| TF name : | Tgfb1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tgfb1 | ALK1 signaling events | pid | 26 |
| Tgfb1 | AP-1 transcription factor network | pid | 71 |
| Tgfb1 | Downregulation of TGF-beta receptor signaling | reactome | 26 |
| Tgfb1 | ECM proteoglycans | reactome | 55 |
| Tgfb1 | Glypican 1 network | pid | 26 |
| Tgfb1 | Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) | inoh | 228 |
| Tgfb1 | Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) | inoh | 239 |
| Tgfb1 | Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) | inoh | 237 |
| Tgfb1 | Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) | inoh | 227 |
| Tgfb1 | Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) | inoh | 228 |
| Tgfb1 | Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) | inoh | 227 |
| Tgfb1 | IL12 signaling mediated by STAT4 | pid | 33 |
| Tgfb1 | IL27-mediated signaling events | pid | 26 |
| Tgfb1 | Molecules associated with elastic fibres | reactome | 30 |
| Tgfb1 | Platelet degranulation | reactome | 107 |
| Tgfb1 | Regulation of Telomerase | pid | 70 |
| Tgfb1 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| Tgfb1 | SMAD2/3 MH2 Domain Mutants in Cancer | reactome | 7 |
| Tgfb1 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | reactome | 6 |
| Tgfb1 | Syndecan-1-mediated signaling events | pid | 42 |
| Tgfb1 | Syndecan-2-mediated signaling events | pid | 38 |
| Tgfb1 | Syndecan interactions | reactome | 20 |
| Tgfb1 | TGF-beta receptor signaling activates SMADs | reactome | 12 |
| Tgfb1 | TGF-beta receptor signaling | pid | 53 |
| Tgfb1 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | reactome | 16 |
| Tgfb1 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| Tgfb1 | TGF beta signaling pathway(through TAK1) ( TGF-beta signaling(through TAK1) ) | inoh | 8 |
| Tgfb1 | TGF_beta_Receptor | netpath | 220 |
| Tgfb1 | TGFBR1 KD Mutants in Cancer | reactome | 7 |
| Tgfb1 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Tgfb1 | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | pid | 42 |
| Tgfb1 | MAPK signaling pathway | kegg | 264 |
| Tgfb1 | Cytokine-cytokine receptor interaction | kegg | 213 |
| Tgfb1 | Cell cycle | kegg | 124 |
| Tgfb1 | Endocytosis | kegg | 201 |
| Tgfb1 | TGF-beta signaling pathway | kegg | 82 |
| Tgfb1 | Intestinal immune network for IgA production | kegg | 48 |
| Tgfb1 | Leishmaniasis | kegg | 71 |
| Tgfb1 | Chagas disease | kegg | 103 |
| Tgfb1 | Malaria | kegg | 50 |
| Tgfb1 | Toxoplasmosis | kegg | 131 |
| Tgfb1 | Amoebiasis | kegg | 103 |
| Tgfb1 | Pathways in cancer | kegg | 321 |
| Tgfb1 | Colorectal cancer | kegg | 63 |
| Tgfb1 | Renal cell carcinoma | kegg | 65 |
| Tgfb1 | Pancreatic cancer | kegg | 70 |
| Tgfb1 | Chronic myeloid leukemia | kegg | 69 |
| Tgfb1 | Hypertrophic cardiomyopathy (HCM) | kegg | 78 |
| Tgfb1 | Dilated cardiomyopathy | kegg | 85 |
| Tgfb1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| Tgfb1 | Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 | wikipathways | 36 |
| Tgfb1 | Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 | wikipathways | 17 |
| Tgfb1 | Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629 | wikipathways | 9 |
| Tgfb1 | Hs_Simplified_Interaction_Map_Between_LOXL4_and_Oxidative_Stress_Pathway_WP3670_90107 | wikipathways | 14 |
| Tgfb1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Tgfb1 | Hs_Allograft_Rejection_WP2328_90020 | wikipathways | 12 |
| Tgfb1 | Hs_ESC_Pluripotency_Pathways_WP3931_91005 | wikipathways | 13 |
| Tgfb1 | Hs_Lung_fibrosis_WP3624_91475 | wikipathways | 23 |
| Tgfb1 | Hs_One_carbon_metabolism_and_related_pathways_WP3940_91096 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer