About Enhancer
| Enhancer ID: | E_03896 |
| Species: | Homo sapiens |
| Position : | chr1:199217982-199218479   |
| Year: | 2020 |
| Title: | Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 32933554 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | CUTLL1 |
| CVCL ID: | CVCL_4966 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF binding assay; Chromatin interaction assay; Chromatin accessibility profiling; Cancer-specific regulatory-site characterization |
| High Throughput Method: | CTCF ChIP-seq; ATAC-seq; in situ Hi-C; RNA-seq; WGS; DNA methylation profiling |
| Low Throughput Method: | ChIP-qPCR; RT-qPCR; Western blot; NOTCH1-pathway perturbation/validation |
About Target Gene
| Target gene : | NA |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer