About Enhancer
| Enhancer ID: | E_03900 |
| Species: | Mus musculus |
| Position : | chr12:25090158-25090663   |
| Year: | 2015 |
| Title: | Id2 deletion attenuates Apc-deficient ileal tumor formation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 26163528 |
| MONDO: | MONDO:0024331 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116,SW480 |
| CVCL ID: | CVCL_0291 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; Western blot; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Id2 |
About TF
| TF name : | Tcf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf4 | AndrogenReceptor | netpath | 167 |
| Tcf4 | CDO in myogenesis | reactome | 29 |
| Tcf4 | Coregulation of Androgen receptor activity | pid | 61 |
| Tcf4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf4 | ID | netpath | 38 |
| Tcf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf4 | TGF_beta_Receptor | netpath | 220 |
| Tcf4 | Wnt | netpath | 118 |
| Tcf4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03943 | chr12:25090158-25096935 | colon | NA | colorectal carcinoma |
Expression of Target Genes for the Enhancer