About Enhancer
| Enhancer ID: | E_03903 |
| Species: | Mus musculus |
| Position : | chr3:34824938-34837938   |
| Year: | 2025 |
| Title: | Functional maps of a genomic locus reveal confinement of an enhancer by its target gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 40966339 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | ES-R1 |
| CVCL ID: | CVCL_2167 |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | CRISPR deletion functional assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; Micro-C, transposon integration mapping; Micro-C |
| Low Throughput Method: | RT-qPCR, flow cytometry |
About Target Gene
| Target gene : | Sox2 |
About TF
| TF name : | Pou5f1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5f1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5f1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5f1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5f1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03351 | chr3:34824938-34837938 | embryo | mouse embryonic stem cell | NA |
| E_03352 | chr3:34824938-34837938 | embryo | mouse embryonic stem cell | NA |
| E_03353 | chr3:34824938-34837938 | embryo | mouse embryonic stem cell | NA |
| E_03902 | chr3:34824938-34837938 | embryo | mouse embryonic stem cell | NA |
| E_03904 | chr3:34824938-34837938 | embryo | mouse embryonic stem cell | NA |
Expression of Target Genes for the Enhancer