About Enhancer
| Enhancer ID: | E_03907 |
| Species: | Homo sapiens |
| Position : | chr11:111343838-111451584   |
| Year: | 2013 |
| Title: | Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 24332044 |
| MONDO: | MONDO:0018905 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | OCI-Ly1 |
| CVCL ID: | CVCL_1879 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Super-enhancer identification; Functional perturbation assay; Drug perturbation assay |
| High Throughput Method: | H3K27ac ChIP-seq; BRD4 ChIP-seq; BCL6 ChIP-seq; RNA polymerase II ChIP-seq; gene expression microarray |
| Low Throughput Method: | JQ1 BET inhibition; POU2AF1 shRNA knockdown; POU2AF1 rescue/overexpression; RT-qPCR; Western blot; proliferation assay; apoptosis assay; xenograft assay |
About Target Gene
| Target gene : | POU2AF1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03927 | chr11:111357554-111446979 | peritoneal fluid | malignant cell | diffuse large B-cell lymphoma |
Expression of Target Genes for the Enhancer