About Enhancer
| Enhancer ID: | E_03910 |
| Species: | Mus musculus |
| Position : | chr3:2931-3443   |
| Year: | 2010 |
| Title: | c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20042469 |
| Tissue: | lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | CD4+ T |
| Cell Type: | CD4-positive T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; RT-RT-qPCR; Western blot; Flow Cytometry; Coimmunoprecipitation |
About Target Gene
| Target gene : | Il21 |
About TF
| TF name : | Foxp3 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxp3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Foxp3 | IL2 signaling events mediated by STAT5 | pid | 30 |
| Foxp3 | Hs_Allograft_Rejection_WP2328_90020 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03909 | chr3:2931-3443 | lymph node | CD4-positive T cell | NA |
Expression of Target Genes for the Enhancer