About Enhancer
| Enhancer ID: | E_03923 |
| Species: | Homo sapiens |
| Position : | chr11:111284123-111290712   |
| Year: | 2013 |
| Title: | Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 24332044 |
| MONDO: | MONDO:0018905 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | OCI-Ly1 |
| CVCL ID: | CVCL_1879 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Super-enhancer profiling; BET dependency assay; Transcriptional perturbation assay |
| High Throughput Method: | BRD4 ChIP-seq; H3K27ac ChIP-seq; H3K4me3 ChIP-seq; H3K27me3 ChIP-seq; RNA polymerase II ChIP-seq; E2F1 ChIP-seq; gene-expression profiling |
| Low Throughput Method: | JQ1 BET inhibition; POU2AF1 RT-qPCR; OCA-B Western blot; OCA-B shRNA knockdown; proliferation assay; cell-cycle analysis; xenograft assay |
About Target Gene
| Target gene : | POU2AF1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04726 | chr11:111250000-111350000 | lymph node | malignant cell | diffuse large B-cell lymphoma |
Expression of Target Genes for the Enhancer