About Enhancer
| Enhancer ID: | E_03924 |
| Species: | Mus musculus |
| Position : | chr3:37229193-37229705   |
| Year: | 2010 |
| Title: | c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20042469 |
| Cell Source: | EL4 |
| CVCL ID: | CVCL_0255 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; Maf and Foxp3 cotransfection; PMA-ionomycin stimulation |
About Target Gene
| Target gene : | Il21 |
About TF
| TF name : | Foxp3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxp3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Foxp3 | IL2 signaling events mediated by STAT5 | pid | 30 |
| Foxp3 | Hs_Allograft_Rejection_WP2328_90020 | wikipathways | 12 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer