About Enhancer
| Enhancer ID: | E_03925 |
| Species: | Mus musculus |
| Position : | chr3:37229193-37229705   |
| Year: | 2010 |
| Title: | c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20042469 |
| Cell Source: | EL4 |
| CVCL ID: | CVCL_0255 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; Maf overexpression; PMA-ionomycin stimulation |
About Target Gene
| Target gene : | Il21 |
About TF
| TF name : | Maf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Maf | AP-1 transcription factor network | pid | 71 |
| Maf | C-MYB transcription factor network | pid | 87 |
| Maf | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Maf | Kaposi sarcoma-associated herpesvirus | mirtarbase | 13 |
| Maf | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer