About Enhancer
| Enhancer ID: | E_03935 |
| Species: | Mus musculus |
| Position : | chr5:147267614-147267639   |
| Year: | 2011 |
| Title: | Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c). |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21652712 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HIT,Hep G2,INS-1 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Pdx1 |
About TF
| TF name : | Pdx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pdx1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Pdx1 | Regulation of gene expression in beta cells | reactome | 17 |
| Pdx1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| Pdx1 | Type II diabetes mellitus | kegg | 44 |
| Pdx1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer