About Enhancer
| Enhancer ID: | E_03950 |
| Species: | Mus musculus |
| Position : | chr9:48814346-48815095   |
| Year: | 2017 |
| Title: | A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29038474 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002370 |
| Cell Source: | NKT thymocyte and ILCP |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Functional perturbation assay; Endogenous enhancer perturbation; TF binding assay; Chromatin-state profiling; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | ATAC-seq, ChIP-seq; ATAC-seq; ChIP-seq |
| Low Throughput Method: | CRISPR Knockout; CRISPR-Cas9 endogenous deletion/editing; ChIP; In vivo phenotyping |
About Target Gene
| Target gene : | Zbtb16 |
About TF
| TF name : | Runx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx1 | AndrogenReceptor | netpath | 167 |
| Runx1 | Organic cation transport | reactome | 9 |
| Runx1 | RANKL | netpath | 84 |
| Runx1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx1 | TGF_beta_Receptor | netpath | 220 |
| Runx1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Runx1 | Pathways in cancer | kegg | 321 |
| Runx1 | Chronic myeloid leukemia | kegg | 69 |
| Runx1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer