About Enhancer
| Enhancer ID: | E_03955 |
| Species: | Homo sapiens |
| Position : | chr17:26072592-26074592   |
| Year: | 2009 |
| Title: | A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 19467240 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep G2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay |
About Target Gene
| Target gene : | NOS2 |
About TF
| TF name : | POU2F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F1 | AndrogenReceptor | netpath | 167 |
| POU2F1 | ATF-2 transcription factor network | pid | 59 |
| POU2F1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| POU2F1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| POU2F1 | FOXA1 transcription factor network | pid | 45 |
| POU2F1 | Glucocorticoid receptor regulatory network | pid | 85 |
| POU2F1 | Regulation of Androgen receptor activity | pid | 54 |
| POU2F1 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F1 | RNA Polymerase III Abortive And Retractive Initiation | reactome | 41 |
| POU2F1 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | reactome | 28 |
| POU2F1 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer