About Enhancer
| Enhancer ID: | E_03961 |
| Species: | Homo sapiens |
| Position : | chr7:114456873-114463136   |
| Year: | 2019 |
| Title: | Functional characterization of two enhancers located downstream FOXP2. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | speech and language disorder / childhood apraxia-associated regulatory locus |
| PMID: | 31046704 |
| MONDO: | MONDO:0004750 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | SK-N-MC |
| CVCL ID: | CVCL_0530 |
| Cell Type: | neural cell model |
| Experiment Type: | Endogenous enhancer deletion and target-gene functional characterization |
| High Throughput Method: | ENCODE chromatin-state integration |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; reporter assay; gene-expression analysis; CRISPR-Cas9 |
About Target Gene
| Target gene : | FOXP2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03962 | chr7:114456873-114463136 | brain | neural cell model | speech and language disorder-associated FOXP2 regulatory locus |
Expression of Target Genes for the Enhancer