About Enhancer
| Enhancer ID: | E_03969 |
| Species: | Mus musculus |
| Position : | chr15:63833002-63863200   |
| Year: | 2017 |
| Title: | ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Colon Cancer |
| PMID: | 27941798 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Arid1a |
About TF
| TF name : | Cebpb |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Cebpb | C-MYB transcription factor network | pid | 87 |
| Cebpb | EGFR1 | netpath | 475 |
| Cebpb | FOXA1 transcription factor network | pid | 45 |
| Cebpb | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Cebpb | IFN-gamma pathway | pid | 43 |
| Cebpb | IL3-mediated signaling events | pid | 27 |
| Cebpb | IL4-mediated signaling events | pid | 66 |
| Cebpb | IL4 | netpath | 75 |
| Cebpb | IL6-mediated signaling events | pid | 48 |
| Cebpb | IL6 | netpath | 85 |
| Cebpb | RANKL | netpath | 84 |
| Cebpb | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Cebpb | Regulation of retinoblastoma protein | pid | 67 |
| Cebpb | Senescence-Associated Secretory Phenotype (SASP) | reactome | 108 |
| Cebpb | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Cebpb | TCR | netpath | 261 |
| Cebpb | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Cebpb | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Cebpb | Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 | wikipathways | 62 |
| Cebpb | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| Cebpb | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
| Cebpb | Hs_Lung_fibrosis_WP3624_91475 | wikipathways | 23 |
| Cebpb | Hs_IL17_signaling_pathway_WP2112_89838 | wikipathways | 20 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer